He was born in Siberia in 1797 to a clerical family, and became a married parish priest in Irkutsk. A devout explorer, John Kriukov, told him of the great spiritual needs among the Russian and native peoples in Alaska, then Russian territory. Moved to serve Christ in this very difficult environment, he and his family arrived in Alaska in 1824. He quickly learned the Aleut language and worked humbly and tirelessly among the Aleuts. His spiritual classic, An Indication of the Way to the Kingdom of Heaven, was originally written in Aleut and later translated into many languages.   While he was visiting Russia in 1838, his wife died; one year later he was tonsured a monk and given the name of Innocent (he had been Fr John Veniaminov). Almost immediately after his tonsuring he was, without warning, raised to the rank of Bishop of all Eastern Siberia and Russian America, probably the largest diocese in the world at that time. Returning to Alaska, he continued his missionary work with vigor, often traveling among Aleut and Tlingit settlements in his own kayak. Wherever he went, he found the Alaskan people hungry for the faith, and his labors bore rich fruit which is still obvious today: Alaska has more Orthodox churches per capita than any other state.   In old age he was made Metropolitan of Moscow, head of the entire Russian Orthodox Church. His concern for Christian mission was undiminished, and as Metropolitan he created the Orthodox Missionary Society. He reposed on Holy Saturday of 1879.

"This monk died joyfully because he had never in his life condemned anyone. He was lazy, careless, disinclined to prayer, but throughout his entire life he had never judged anyone. And when he lay dying, he was full of joy. The brethren asked him how he could die so joyfully with all his sins, and he replied: 'I have just seen the angels, and they showed me a page with all my many sins. I said to them: "The Lord said: 'Judge not, that ye be not judged.' I have never judged anyone and I hope in the mercy of God, that He will not judge me." And the angels tore up the sheet of paper.' Hearing this, the monks wondered at it and learned from it." (From the Prologue)

"He was the son of Juliana, a Christian woman of Armenia. While still a child, he left his mother and ran off to the desert. He was utterly aflame with love for Christ the Lord. In the beginning he entrusted himself to the guidance of a spiritual father, Pharmutius, who was so pleasing to God that an angel brought him bread every day. John later left him and withdrew into solitude. He let himself down into a dry well and lived there for a full ten years in fasting, prayer and vigils. St Pharmutius used to bring him some of the angel's bread, for the angel of God did not wish to bring bread to the young John in person, lest he grow proud through this, so sent it through Pharmutius his spiritual father. After ten years of arduous asceticism in his well, St John went to the Lord and his relics revealed wonderworking power. He lived and was glorified by God and men in the 4th century." (Prologue)

He took up the monastic life when very young, and lived as a recluse for many years, and gained the grace to heal sicknesses and drive out demons by his prayers. Later he became abbot of the Monastery of Pelekete in Bithynia. During the reign of the Emperor Leo the Isaurian, he and his monastery steadfastly upheld the holy icons, and were fiercely persecuted. Hilarion and his forty monks were exiled to a prison near Ephesus, where the Saint reposed.

She was a servant of the Jewish wife of the governor of Thessalonica. When she refused to enter the synagogue with her mistress, she was beaten, then locked in a cell until she starved to death. Finally, her mistress ordered her body thrown from the roof of the house and left to lie in the open. Christians took her body and buried it honorably, and the bishop, Alexander, built a church over her grave.